High quality CAS no:159351-69-6 Everolimus
Basic Info
Model No.: S.Y-A
Product Description
Description of Everolimus
Application of Everolimus Everolimus exhibits the immunosuppressive activity which is comparable to that of rapamycin. Everolimus competes with immobilized FK 506 for binding to biotinylated FKBP12 and shows the inhibitory effect on a two-way MLR performed with spleen cells from BALB/c and CBA mice with IC50 of 0.12-1.8 nM. Everolimus also shows antiangiogenic/vascular effects in VEGF-induced HUVEC proliferation with IC50 of 0.12 nM and bFGF-induced HUVEC proliferation with IC50 of 0.8 nM, respectively. A recent study shows that Everolimus shows a dose-dependent inhibitory effects on both the total cells and the stem cells from the BT474 cell line and the primary breast cancer cells with IC50 of 156 nM in total cells of primary breast cancer cells and 71 nM in total cells of BT474 cells. In addition, combination treatment with Everolimus and trastuzumab produces the significantly increased inhibition on the growth of cancer stem cells with the inhibition rate increased by more than 50 %.
packing&storage package:25kg/drum,double plastic-bag inside,aluminum foil bag or fiber drum outside. storage:stored in a clean,cool, dry area;keep away frommoisture and stong,direct light/heat. shelf life: two years when properly stored 
about us HENAN SENYUAN BIOLOGICAL TECHNOLOGYCo., Ltd.is an effectivecomponent in natural plants pharmaceutical intermediates and the development, production, sales of high-tech enterprises. Is dedicated to promoting traditional Chinese herbs modernization process, widely used in Chinese Medicine, chemicals, food, health products industries, providing high-quality products and improve the technology and after-sales service. 
our services 1. Any inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. OEM/ODM Available. 5. Reasonable & competitive price, fast lead time. 6. Sample is available for your evaluation & Formulation development. 7. Faster delivery: Sample order in stock and 3-7 days for bulk production. 8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder. 9. After-Sale Service: 1)International Authorized Third-Party Test For The Products You Demand. 2)60 Days Warranty of quality of goods. 
FAQ Q1: Can i get some samples? A: Yes, we can supply the free sample, but the shipping cost be paid by our customers. Q2: How to start orders or make payments? A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba). Q3: How to confirm the Product Quality before placing orders? A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. Q4:What’s your MOQ? A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid. Q5: How about delivery leadtime? A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included) Q6:Is there a discount? A:Different quantity has different discount. Q7: How do you treat quality complaint? A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. Q8: How to contact us ? A:You can chat with us by Trademanager,MSN&Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us. 
Contact us if you need more details on Everolimus. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 159351-69-6、Anti-cancer Drug Everolimus. If these products fail to match your need, please contact us and we would like to provide relevant information.
| Product Name: Everolimus |
| Synonyms: 40-O-(2-Hydroxyethyl)rapamycin;42-O-(2-Hydroxy)ethylrapamycin |
| Cas No.: 159351-69-6 |
| Apperarnce: white powder |
| M.Wt: 958.25 Formula: C53H83NO14 Solubility: DMSO |
Application of Everolimus Everolimus exhibits the immunosuppressive activity which is comparable to that of rapamycin. Everolimus competes with immobilized FK 506 for binding to biotinylated FKBP12 and shows the inhibitory effect on a two-way MLR performed with spleen cells from BALB/c and CBA mice with IC50 of 0.12-1.8 nM. Everolimus also shows antiangiogenic/vascular effects in VEGF-induced HUVEC proliferation with IC50 of 0.12 nM and bFGF-induced HUVEC proliferation with IC50 of 0.8 nM, respectively. A recent study shows that Everolimus shows a dose-dependent inhibitory effects on both the total cells and the stem cells from the BT474 cell line and the primary breast cancer cells with IC50 of 156 nM in total cells of primary breast cancer cells and 71 nM in total cells of BT474 cells. In addition, combination treatment with Everolimus and trastuzumab produces the significantly increased inhibition on the growth of cancer stem cells with the inhibition rate increased by more than 50 %.
packing&storage package:25kg/drum,double plastic-bag inside,aluminum foil bag or fiber drum outside. storage:stored in a clean,cool, dry area;keep away frommoisture and stong,direct light/heat. shelf life: two years when properly stored 
about us HENAN SENYUAN BIOLOGICAL TECHNOLOGYCo., Ltd.is an effectivecomponent in natural plants pharmaceutical intermediates and the development, production, sales of high-tech enterprises. Is dedicated to promoting traditional Chinese herbs modernization process, widely used in Chinese Medicine, chemicals, food, health products industries, providing high-quality products and improve the technology and after-sales service. 
our services 1. Any inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. OEM/ODM Available. 5. Reasonable & competitive price, fast lead time. 6. Sample is available for your evaluation & Formulation development. 7. Faster delivery: Sample order in stock and 3-7 days for bulk production. 8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder. 9. After-Sale Service: 1)International Authorized Third-Party Test For The Products You Demand. 2)60 Days Warranty of quality of goods. 
FAQ Q1: Can i get some samples? A: Yes, we can supply the free sample, but the shipping cost be paid by our customers. Q2: How to start orders or make payments? A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba). Q3: How to confirm the Product Quality before placing orders? A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. Q4:What’s your MOQ? A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid. Q5: How about delivery leadtime? A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included) Q6:Is there a discount? A:Different quantity has different discount. Q7: How do you treat quality complaint? A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. Q8: How to contact us ? A:You can chat with us by Trademanager,MSN&Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us. 
Contact us if you need more details on Everolimus. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 159351-69-6、Anti-cancer Drug Everolimus. If these products fail to match your need, please contact us and we would like to provide relevant information. Product Categories : Nutritional Supplement
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